Nottinghamshire Area Prescribing Committee
Joint Formulary
 
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15 Anaesthesia
15-01-07 Antagonists for central and respiratory depression

Doxapram Dopram®
Formulary
See section 3.5.1

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Flumazenil
Formulary
Injection
  • See poisoning section for further information

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    Naloxone
    Formulary
    Injection 400mcg/ml
    Injection 40mcg/2ml (unlicensed)
    Link  NUH Lite Bite: Adult Naloxone Guidelines Updated (July 18)
    Link  NUH memo: Long term supply problem with Naloxone Minijet
    Link  NUH: Guideline for the use of naloxone in adults
    Link  Safety alert: Risk of death with naloxone in long term opioid patients
    Link  SFH: Naloxone infusion guidance
    Link  UKMI Q&A further reading on naloxone usage
     

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    Naloxone pre-filled syringes Prenoxad®
    Formulary

    Prefilled syringes (2mg/2ml)

    • As of October 2017, all Prenoxad syringe packaging is being labelled as 0.91mg/ml, rather than 1mg/ml. The use of the product and dose is unchanged.

    At SFH:

    • On the advice of the Drug and Alcohol Liason Team (DALT) only for patients at high risk of opioid overdose at discharge. DALT will provide patient training. Usually supply one syringe on discharge.

    In Nottingham City CCG:

    • Available as part of 1 year pilot for the treatment of opioid overdose in a non-medical setting. Classified as Green for duration of pilot.
    • Prescribers should be satisfied that the patient has undergone appropriate training from the Health Shop (able to produce certificate) or similar organisation. Most patients will be supplied via PGD by substance misuse services, but small numbers of patients may require a prescription from GP.
    Link  Guides and Information leaflets - Naloxone pre-filled syringes
     

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    Naloxone nasal spray Nyxoid®
    Non Formulary

    No formal assessment


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